Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

Lee, Hyun Jun; Seo, Young Eun; Han, Seung Beom; Jeong, Dae Chul; Kang, Jin Han

Demographic data included age and sex. Clinical data included birth history, the presence of siblings, the presence of underlying medical conditions, duration of fever and hospitalization, presenting symptoms on admission, final diagnosis on discharge, and severity of the ADV infection. Fever was defined when the tympanic membrane temperature was ≥38.0 ºC. Among presenting symptoms, respiratory symptoms included cough, rhinorrhea, sputum, nasal stuffiness and dyspnea, and gastrointestinal symptoms included vomiting, diarrhea and abdominal pain. Ophthalmologic symptoms included conjunctival injection, ocular pruritus, ocular pain and eye discharges. Neurologic symptoms included dizziness, headache and seizure-like motion, and dermatologic symptoms included various types of skin rashes. The ADV infection was considered severe in cases where oxygen therapy was given; the demand for oxygen increased in a child who had already received oxygen therapy; a child was admitted to the intensive care unit (ICU); or a child died due to the ADV infection. On admission, blood tests were performed to assess total and differential white blood cell counts and platelet counts. In addition, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), aspartate transaminase, and alanine transaminase levels were also assessed at admission. Demographic, clinical, and laboratory parameters were compared between the two children groups. This study was approved by the Institutional Review Board of Seoul St. Mary's Hospital (Approval No.: KC15RISI0767). Informed consent was waived for this study.