Selected article for: "classical pathway and complement activation"
Author: Avirutnan, Panisadee; Hauhart, Richard E.; Marovich, Mary A.; Garred, Peter; Atkinson, John P.; Diamond, Michael S.
Title: Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin
  • Document date: 2011_12_13
    • ID: 1x3n5job_22
    Snippet: creased risk of DENV-induced thrombocytopenia with wild-type but not low-producer MBL genotypes (45) , another found no effect of MBL variation on the risk of severe dengue infection (46) . However, the vast majority of patients from these studies were experiencing secondary dengue infection, when cross-reactive complement-fixing antibodies are present. MBL opsonization could protect against primary DENV infection (when anti-DENV antibodies are a.....
    Document: creased risk of DENV-induced thrombocytopenia with wild-type but not low-producer MBL genotypes (45) , another found no effect of MBL variation on the risk of severe dengue infection (46) . However, the vast majority of patients from these studies were experiencing secondary dengue infection, when cross-reactive complement-fixing antibodies are present. MBL opsonization could protect against primary DENV infection (when anti-DENV antibodies are absent or at low levels) yet be overshadowed during secondary DENV infection when antibody-mediated classical pathway-dependent complement activation occurs. At present, it is poorly understood why the majority (up to almost 90% in some studies) of primary DENV infections are asymptomatic (47) (48) (49) .

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