Author: Kammer, Andreas R.; van der Burg, Sjoerd H.; Grabscheid, Benno; Hunziker, Isabelle P.; Kwappenberg, Kitty M.C.; Reichen, Jürg; Melief, Cornelis J.M.; Cerny, Andreas
Title: Molecular Mimicry of Human Cytochrome P450 by Hepatitis C Virus at the Level of Cytotoxic T Cell Recognition Document date: 1999_7_19
ID: 1vabzhs5_27
Snippet: Our findings demonstrate the potential of HCV to induce autoreactive CD8 Ï© CTLs by a molecular mimicry of CYP2A6/2A7 by the core protein and therefore show a possible mechanism by which HCV may trigger AIH. Further studies analyzing the cross-reactivity pattern of HCV core-specific CTLs derived from untreated patients with active HCV-associated autoimmune hepatitis are required in order to establish this mechanism......
Document: Our findings demonstrate the potential of HCV to induce autoreactive CD8 Ï© CTLs by a molecular mimicry of CYP2A6/2A7 by the core protein and therefore show a possible mechanism by which HCV may trigger AIH. Further studies analyzing the cross-reactivity pattern of HCV core-specific CTLs derived from untreated patients with active HCV-associated autoimmune hepatitis are required in order to establish this mechanism.
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