Author: Daniels, Keith A.; Devora, Gene; Lai, Wayne C.; O'Donnell, Carey L.; Bennett, Michael; Welsh, Raymond M.
Title: Murine Cytomegalovirus Is Regulated by a Discrete Subset of Natural Killer Cells Reactive with Monoclonal Antibody to Ly49h Document date: 2001_7_2
ID: 6n3dmle6_35
Snippet: In six experiments with MHV, using virus inoculum doses ranging from 5 ϫ 10 4 to 10 6 PFUs, treatment with anti-NK1.1 only led to small increases in the titers of MHV in the liver; average titers in control groups ranged from 3.8 to 4.9 log 10 PFUs per organ, and average increase in titer in paired groups treated with anti-NK1.1 was 0.28 Ϯ 0.3. Spleen titers were all Ͻ10 3 PFUs, and in three of six experiments viral titers were beneath the 2 l.....
Document: In six experiments with MHV, using virus inoculum doses ranging from 5 ϫ 10 4 to 10 6 PFUs, treatment with anti-NK1.1 only led to small increases in the titers of MHV in the liver; average titers in control groups ranged from 3.8 to 4.9 log 10 PFUs per organ, and average increase in titer in paired groups treated with anti-NK1.1 was 0.28 Ϯ 0.3. Spleen titers were all Ͻ10 3 PFUs, and in three of six experiments viral titers were beneath the 2 log 10 detection limit. For those reasons MHV titers were not examined in mAb 1F8-treated mice.
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