Author: Chattopadhyay, Saborni; Chen, Jui-Yi; Chen, Hui-Wen; Hu, Che-Ming Jack
Title: Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation Document date: 2017_6_9
ID: 7q2wkwrf_14
Snippet: A wide variety of polymers have been applied to the development of nanoparticle vaccines. Synthetic polymeric nanoparticles are typically solid particles between 10 nm to 200 nm. They have been an attractive platform for vaccine delivery as antigens and adjuvants can be either surface attached to or interior loaded inside these nanoparticles [55] [56] [57] [58] [59] . In particular, controlled release of biomolecules is one of the strongest advan.....
Document: A wide variety of polymers have been applied to the development of nanoparticle vaccines. Synthetic polymeric nanoparticles are typically solid particles between 10 nm to 200 nm. They have been an attractive platform for vaccine delivery as antigens and adjuvants can be either surface attached to or interior loaded inside these nanoparticles [55] [56] [57] [58] [59] . In particular, controlled release of biomolecules is one of the strongest advantage of polymeric nanoparticles, the release kinetics of which can be regulated by tuning of the copolymer composition and molecular weight [55] . Typically, polymeric nanoparticles are formed via self-assembly of amphiphilic copolymers under an emulsion or nanoprecipitation process [60] [61] [62] . Notable polymeric nanoparticles in vaccine development are as follows.
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