Author: Jartti, Laura; Langen, Henriikka; Söderlund-Venermo, Maria; Vuorinen, Tytti; Ruuskanen, Olli; Jartti, Tuomas
Title: New Respiratory Viruses and the Elderly Document date: 2011_7_6
ID: 7fwzohmu_36
Snippet: Current knowledge on bacterial-viral coinfections in the elderly is very limited. In community-acquired pneumonia of adults, there is evidence of mixed viral-bacterial infection in up to 15% of cases and in children up to 45 % of cases [179] . The most frequent combinations have been Streptococcus pneumoniae with influenza A virus or HRV. Bacterial and viral infections may act deleteriously through synergistic mechanisms. There may be destruction.....
Document: Current knowledge on bacterial-viral coinfections in the elderly is very limited. In community-acquired pneumonia of adults, there is evidence of mixed viral-bacterial infection in up to 15% of cases and in children up to 45 % of cases [179] . The most frequent combinations have been Streptococcus pneumoniae with influenza A virus or HRV. Bacterial and viral infections may act deleteriously through synergistic mechanisms. There may be destruction of the respiratory epithelium by the viral infection, which may increase bacterial adhesion; virus-induced immunosuppression may cause bacterial superinfections; and the inflammatory response to viral infection may up-regulate the expression of molecules that are suitable for bacteria as receptors [180] .
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