Selected article for: "neonatal calf and present study"
Author: Todd, C. G.; Millman, S. T.; McKnight, D. R.; Duffield, T. F.; Leslie, K. E.
Title: Nonsteroidal anti-inflammatory drug therapy for neonatal calf diarrhea complex: Effects on calf performance
  • Document date: 2010_6_23
    • ID: 326huu05_3
    Snippet: It has been reported that altering the activity of cyclooxygenase-2 (COX-2) may be a way of mitigating sickness behavior and enhancing disease recovery (Lugarini et al., 2002) . Meloxicam (MEL) is a nonsteroidal anti-inflammatory drug (NSAID) that preferentially inhibits COX-2 and has a half-life of approximately 26 h in bovine plasma (European Agency for the Evaluation of Medicinal Products, 2007) . A field study reported that MEL administration.....
    Document: It has been reported that altering the activity of cyclooxygenase-2 (COX-2) may be a way of mitigating sickness behavior and enhancing disease recovery (Lugarini et al., 2002) . Meloxicam (MEL) is a nonsteroidal anti-inflammatory drug (NSAID) that preferentially inhibits COX-2 and has a half-life of approximately 26 h in bovine plasma (European Agency for the Evaluation of Medicinal Products, 2007) . A field study reported that MEL administration to calves with diarrhea resulted in improvements in clinical variables (Philipp et al., 2003) . The objective of the present study was to examine the efficacy of MEL as a supportive therapy for calves with neonatal calf diarrhea complex. The hypothesis underlying this study was that NSAID therapy at the onset of diarrhea would attenuate sickness behavior, as well as alleviate malaise and gastrointestinal discomfort, thereby encouraging calves to maintain a strong appetite during sickness and supporting calf performance.

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