Selected article for: "antibiotic therapy and bacterial infection"
Author: Joseph, Patrick; Godofsky, Eliot
Title: Outpatient Antibiotic Stewardship: A Growing Frontier—Combining Myxovirus Resistance Protein A With Other Biomarkers to Improve Antibiotic Use
  • Document date: 2018_2_15
    • ID: 0emio4rl_6
    Snippet: Efficiently defining a clinically significant bacterial infection requiring antibiotic therapy is the rate-limiting step of antibiotic stewardship in the outpatient setting. Biomarkers such as C-reactive protein (CRP) or procalcitonin (PCT) independently may identify clinically significant infections, thereby reducing the risk of missing a clinically significant bacterial infection. However, these biomarkers lack adequate specificity to different.....
    Document: Efficiently defining a clinically significant bacterial infection requiring antibiotic therapy is the rate-limiting step of antibiotic stewardship in the outpatient setting. Biomarkers such as C-reactive protein (CRP) or procalcitonin (PCT) independently may identify clinically significant infections, thereby reducing the risk of missing a clinically significant bacterial infection. However, these biomarkers lack adequate specificity to differentiate a viral from a bacterial infection and ultimately lead to antibiotic overtreatment of viral infections. Myxovirus resistance protein A (MxA), a protein induced by type I interferon, is selectively elevated in patients with viral infections and has the potential to greatly enhance the rapid distinction between viral and bacterial respiratory infections [7, 8] . Combining CRP or PCT with an elevated MxA will help identify patients who most likely have viral infection, allowing physicians to consider reserving antibiotics in this patient population and proceed with a watchful, waiting strategy.

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