Author: Li, Xinyu; Huang, Lei; Gao, Weijie
Title: Overexpression of Tripartite Motif Conaining 55 (TRIM55) Inhibits Migration and Invasion of Hepatocellular Carcinoma (HCC) Cells via Epithelial-Mesenchymal Transition and Matrix Metalloproteinase-2 (MMP2) Document date: 2019_1_27
ID: 037d5r9i_21
Snippet: To investigate the relationship between TRIM55 expression and prognosis of HCC patients, we divided these 100 cases into a TRIM55 high group and a TRIM55 low group. Kaplan-Meier analysis showed that patients with low expression of TRIM55 always had a worse prognosis than those with high expression of TRIM55 (p=0.010) (Figure1B) . Cox regression analysis showed that TRIM55 was an independent risk factor of HCC patients (HR=0.425, 95%CI=(0.193-0.93.....
Document: To investigate the relationship between TRIM55 expression and prognosis of HCC patients, we divided these 100 cases into a TRIM55 high group and a TRIM55 low group. Kaplan-Meier analysis showed that patients with low expression of TRIM55 always had a worse prognosis than those with high expression of TRIM55 (p=0.010) (Figure1B) . Cox regression analysis showed that TRIM55 was an independent risk factor of HCC patients (HR=0.425, 95%CI=(0.193-0.934), p=0.033) ( Table 2) . To further verify our findings, we analyzed the relationship between TRIM55 expression and prognosis of HCC patients by TCGA database, and the result was consistent with our previous results (Figure1C). We found that TRIM55 expression is an independent risk factor of HCC patients, and TRIM55 can act as a tumor-suppressor gene during progression of HCC.
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