Author: Tornai, David; Furi, Istvan; Shen, Zu T.; Sigalov, Alexander B.; Coban, Sahin; Szabo, Gyongyi
Title: Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice Document date: 2018_10_29
ID: 35jfg45k_35
Snippet: The clinical progression of ALD is associated with liver fibrosis. (27) Our mouse model of ALD mimics the early phase of the human disease, yet mRNA levels of early fibrosis markers Pro-Col1α and α-SMA were significantly increased in alcohol-fed mice compared to PF controls in the whole-liver samples (Fig. 6A,B) . Induction of these makers was remarkably attenuated in the vehicle-treated group and, importantly, further decreased by the TREM-1 i.....
Document: The clinical progression of ALD is associated with liver fibrosis. (27) Our mouse model of ALD mimics the early phase of the human disease, yet mRNA levels of early fibrosis markers Pro-Col1α and α-SMA were significantly increased in alcohol-fed mice compared to PF controls in the whole-liver samples (Fig. 6A,B) . Induction of these makers was remarkably attenuated in the vehicle-treated group and, importantly, further decreased by the TREM-1 inhibitory formulations used (Fig. 6A,B) .
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