Selected article for: "increase production and inflammatory cytokine"
Author: Tornai, David; Furi, Istvan; Shen, Zu T.; Sigalov, Alexander B.; Coban, Sahin; Szabo, Gyongyi
Title: Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice
  • Document date: 2018_10_29
    • ID: 35jfg45k_43
    Snippet: TREM-1 activation alone has been shown to increase the production of proinflammatory chemokines and cytokines. (39) Furthermore, simultaneous stimulation of TREM-1 and TLRs by an agonistic anti-TREM-1 antibody and different TLR ligands synergized in the induction of these proinflammatory molecules. TREM-1 and TLR4 costimulated monocytes showed increased production of MCP-1, IL-1β, and IL-8. In contrast, the level of the anti-inflammatory cytokin.....
    Document: TREM-1 activation alone has been shown to increase the production of proinflammatory chemokines and cytokines. (39) Furthermore, simultaneous stimulation of TREM-1 and TLRs by an agonistic anti-TREM-1 antibody and different TLR ligands synergized in the induction of these proinflammatory molecules. TREM-1 and TLR4 costimulated monocytes showed increased production of MCP-1, IL-1β, and IL-8. In contrast, the level of the anti-inflammatory cytokine IL-10 decreased when anti-TREM-1 antibody and the TLR3 ligand poly(I:C) or the TLR4 ligand LPS simultaneously attached to their receptors. (40) Because self-perpetuating proinflammatory pathways are present in alcoholic hepatitis, interruption of these pathways using TREM-1 inhibition seems attractive.

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