Author: Abes, Rachida; Moulton, Hong M.; Clair, Philippe; Yang, Sung-Tae; Abes, Said; Melikov, Kamran; Prevot, Paul; Youngblood, Derek S.; Iversen, Patrick L.; Chernomordik, Leonid V.; Lebleu, Bernard
Title: Delivery of steric block morpholino oligomers by (R-X-R)(4) peptides: structure–activity studies Document date: 2008_9_16
ID: 5j496cx0_4
Snippet: Of possible relevance, (R-Ahx-R) 4 -PMO conjugates bind less strongly to heparin (taken as a model heparan sulfate) than Tat-or (Arg) n -PMO conjugates (3) . This could provide an explanation if one assumes that heparan sulfate-bound material has to be released during endocytosis in order to escape to the cell cytoplasm. While sufficient affinity is essential for cell binding and cellular uptake, a too high affinity could become detrimental at la.....
Document: Of possible relevance, (R-Ahx-R) 4 -PMO conjugates bind less strongly to heparin (taken as a model heparan sulfate) than Tat-or (Arg) n -PMO conjugates (3) . This could provide an explanation if one assumes that heparan sulfate-bound material has to be released during endocytosis in order to escape to the cell cytoplasm. While sufficient affinity is essential for cell binding and cellular uptake, a too high affinity could become detrimental at later steps, a hypothesis which we aim to investigate here.
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