Author: Abes, Rachida; Moulton, Hong M.; Clair, Philippe; Yang, Sung-Tae; Abes, Said; Melikov, Kamran; Prevot, Paul; Youngblood, Derek S.; Iversen, Patrick L.; Chernomordik, Leonid V.; Lebleu, Bernard
Title: Delivery of steric block morpholino oligomers by (R-X-R)(4) peptides: structure–activity studies Document date: 2008_9_16
ID: 5j496cx0_60
Snippet: Altogether these SAR studies have pointed to the influence of heparin affinity and hydrophobicity on the splice correcting activity of CPP-PMO conjugates. Remarkably, relatively small changes in these parameters had a rather significant impact on biological activity. Quite clearly, cellular uptake could not be an explanation since, on the contrary, we have observed in some instances an inverse correlation between cellular uptake and biological ac.....
Document: Altogether these SAR studies have pointed to the influence of heparin affinity and hydrophobicity on the splice correcting activity of CPP-PMO conjugates. Remarkably, relatively small changes in these parameters had a rather significant impact on biological activity. Quite clearly, cellular uptake could not be an explanation since, on the contrary, we have observed in some instances an inverse correlation between cellular uptake and biological activity.
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