Selected article for: "accessory protein and viral replication"
Author: Fung, To Sing; Liu, Ding Xiang
Title: Post-translational modifications of coronavirus proteins: roles and function
  • Document date: 2018_5_21
    • ID: 38c28tw1_42
    Snippet: The accessory protein 3b of TGEV is encoded between the S and M genes in the Purdue strain, but it is truncated in some lab-passaged strains. TGEV 3b protein is translated via an internal entry mechanism, possibly in conjunction with leaky scanning [170] . In cells infected with the Purdue strain of TGEV, two forms of 3b protein were detected: a 31 kDa N-glycosylated, membrane-associated form and a 20 kDa nonglycosylated soluble form [171] . The .....
    Document: The accessory protein 3b of TGEV is encoded between the S and M genes in the Purdue strain, but it is truncated in some lab-passaged strains. TGEV 3b protein is translated via an internal entry mechanism, possibly in conjunction with leaky scanning [170] . In cells infected with the Purdue strain of TGEV, two forms of 3b protein were detected: a 31 kDa N-glycosylated, membrane-associated form and a 20 kDa nonglycosylated soluble form [171] . The TGEV 3b protein was not essential for viral replication and was not incorporated in mature virion. Its role in pathogenesis is not completely understood, although deletion of ORF3b was found in some naturally attenuated TGEV strains such as Miller M60 [172] .

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