Author: Fung, To Sing; Liu, Ding Xiang
Title: Post-translational modifications of coronavirus proteins: roles and function Document date: 2018_5_21
ID: 38c28tw1_50
Snippet: Accumulating evidence suggests that coronavirus proteins are subjected to various PTMs by the host cells. Transmembrane structural proteins (S, E and M), nonstructural proteins (nsp3 and nsp4) and accessory proteins (SARS-CoV 3a) are modified by glycosylation. Although glycosylation of coronavirus S protein is essentially Nlinked, the M proteins of lineage A Betacoronavirus adopt the special O-linked glycans, while the M proteins of other coronav.....
Document: Accumulating evidence suggests that coronavirus proteins are subjected to various PTMs by the host cells. Transmembrane structural proteins (S, E and M), nonstructural proteins (nsp3 and nsp4) and accessory proteins (SARS-CoV 3a) are modified by glycosylation. Although glycosylation of coronavirus S protein is essentially Nlinked, the M proteins of lineage A Betacoronavirus adopt the special O-linked glycans, while the M proteins of other coronaviruses are modified by N-linked glycosylation. Some coronavirus S and E proteins acquire palmitoylation in the cytosolic cysteine residues, while the N protein is mainly phosphorylated by multiple host kinases.
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