Author: Welch, Matthew D.
Title: Why should cell biologists study microbial pathogens? Document date: 2015_12_1
ID: 04xyhhmf_23
Snippet: A second example highlights how the study of pathogens can reveal new pathways that influence autophagy, such as an emerging link between cytoskeletal elements and the autophagy machinery (Mostowy, 2014) . In the case of L. monocytogenes, the ability of the bacterial ActA protein to recruit actin-polymerizing factors masks the bacteria from ubiquitination and the initiation of autophagosome formation (Yoshikawa et al., 2009 ). This suggests a pot.....
Document: A second example highlights how the study of pathogens can reveal new pathways that influence autophagy, such as an emerging link between cytoskeletal elements and the autophagy machinery (Mostowy, 2014) . In the case of L. monocytogenes, the ability of the bacterial ActA protein to recruit actin-polymerizing factors masks the bacteria from ubiquitination and the initiation of autophagosome formation (Yoshikawa et al., 2009 ). This suggests a potential role for actin in autophagy inhibition. In contrast, for S. flexneri, recruitment of actin promotes the subsequent recruitment of septin proteins, which cage the bacteria and are crucial for autophagy (Mostowy et al., 2010 (Mostowy et al., , 2011 . Thus, in the case of S. flexneri, actin and septins play a stimulatory role in autophagy. Deciphering the roles of cytoskeletal elements in autophagy regulation and the innate immune response should be an active area of future investigation.
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