Author: Riede, O; Seifert, K; Oswald, D; Endmann, A; Hock, C; Winkler, A; Salguero, F J; Schroff, M; Croft, S L; Juhls, C
Title: Preclinical safety and tolerability of a repeatedly administered human leishmaniasis DNA vaccine Document date: 2015_4_30
ID: 4eyn7pjq_5
Snippet: LEISHDNAVAX is systemically distributed after intradermal administration Biodistribution of the vaccine was assessed in rats after intradermal (i.d.) injection of a 120 μg dose. Total DNA was extracted from tissue samples taken 24 h post injection and MIDGE-Th1 vector DNA quantified using a quantitative PCR (qPCR) assay. Vector DNA was found in a varying number of animals per group and in all tissues except for bone marrow (Figure 1a ). The vect.....
Document: LEISHDNAVAX is systemically distributed after intradermal administration Biodistribution of the vaccine was assessed in rats after intradermal (i.d.) injection of a 120 μg dose. Total DNA was extracted from tissue samples taken 24 h post injection and MIDGE-Th1 vector DNA quantified using a quantitative PCR (qPCR) assay. Vector DNA was found in a varying number of animals per group and in all tissues except for bone marrow (Figure 1a ). The vector copy numbers per μg total DNA ranged from 4.04 × 10 3 (geometric mean, ovaries, 4/5 animals positive) to 2.55 × 10 9 (geometric mean, skin of injection site, all animals positive).
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