Author: Hongzhou Lu; Jingwen Ai; Yinzhong Shen; Yang Li; Tao Li; Xian Zhou; Haocheng Zhang; Qiran Zhang; Yun Ling; Sheng Wang; Hongping Qu; Yuan Gao; Yingchuan Li; Kanglong Yu; Duming Zhu; Hecheng Zhu; Rui Tian; Mei Zeng; Qiang Li; Yuanlin Song; Xiangyang Li; Jinfu Xu; Jie Xu; Enqiang Mao; Bijie Hu; Xin Li; Lei Zhu; Wenhong Zhang
Title: A descriptive study of the impact of diseases control and prevention on the epidemics dynamics and clinical features of SARS-CoV-2 outbreak in Shanghai, lessons learned for metropolis epidemics prevention Document date: 2020_2_23
ID: dbzrd23n_62
Snippet: Our study showed relatively comprehensive laboratory test results in the published 334 studies. Assessed through this systematic inspection, we can find that sever COVID-19 335 cases had extensive systemic laboratory abnormalities which indicated multisystem 336 involvement had existed before significant respiratory abnormalities appeared. Previous 337 studies have found that most patients had reduced lymphocytes and abnormal levels of 338 many c.....
Document: Our study showed relatively comprehensive laboratory test results in the published 334 studies. Assessed through this systematic inspection, we can find that sever COVID-19 335 cases had extensive systemic laboratory abnormalities which indicated multisystem 336 involvement had existed before significant respiratory abnormalities appeared. Previous 337 studies have found that most patients had reduced lymphocytes and abnormal levels of 338 many cytokines in critically ill patients [8, 16] . Lymphocyte classification in our study showed 339 that CD4 and CD8 cells both decreased in COVID-19 patients, and ~15% patients had 340 CD4 / CD8 <1. This may be related to a systemic inflammatory response caused by a 341 cytokine storm, which is similar to that of SARS patients. The severity classification of 342 COVID-19 patients in China mainly focuses on the respiratory system and oxygenation of 343 patients. We believe more attention should be paid to other organs function of the patient 344 in addition to the respiratory system. As follow-up continues, we can observe the outcome 345 of more and more patients, and it should be possible to identify early risk factors that 346 indicate a poor prognosis. 347
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