Selected article for: "RNA structure and secondary structure"
Author: Tuplin, A.; Evans, D. J.; Buckley, A.; Jones, I. M.; Gould, E. A.; Gritsun, T. S.
Title: Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus
  • Document date: 2011_5_27
    • ID: 0aiaklrn_63
    Snippet: In conclusion, bioinformatic analysis demonstrated the presence of a conserved RNA secondary structure in the C coding region of the divergent TBFV group. Disruption of this structure compromised virus replication implying an REE function for SL6. By homology with the TBFVs, SL6-like structures were observed in the genomes of some MBFVs and plausibly indicate a similar role as replication enhancers. Future studies using sub-genomic replicons will.....
    Document: In conclusion, bioinformatic analysis demonstrated the presence of a conserved RNA secondary structure in the C coding region of the divergent TBFV group. Disruption of this structure compromised virus replication implying an REE function for SL6. By homology with the TBFVs, SL6-like structures were observed in the genomes of some MBFVs and plausibly indicate a similar role as replication enhancers. Future studies using sub-genomic replicons will allow direct measurement of the influence of these sequences on RNA replication and on interaction with viral and host proteins.

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