Author: Carvalho, Miguel F.; Gill, Davinder
Title: Rotavirus vaccine efficacy: current status and areas for improvement Document date: 2018_9_19
ID: 14a5861f_28
Snippet: Based on the outcome of 'omics' analysis regarding mucosal immunity, it may be possible to hypothesize on candidate mucosal adjuvants that could lead to increased antigenspecific cell based immunity and also IgA secretion in the gut. These could potentially be administered via intradermal route using e.g. microneedles, therefore bypassing the constraints associated with enteropathy and the requirements for a cold chain. 101 Alternative, potential.....
Document: Based on the outcome of 'omics' analysis regarding mucosal immunity, it may be possible to hypothesize on candidate mucosal adjuvants that could lead to increased antigenspecific cell based immunity and also IgA secretion in the gut. These could potentially be administered via intradermal route using e.g. microneedles, therefore bypassing the constraints associated with enteropathy and the requirements for a cold chain. 101 Alternative, potentially low-cost strategies for vaccine production and storage such as transgenic plants seem to be gaining traction as exemplified by the oral delivery of rice expressing cholera toxins. 70 In principle, this approach could also be explored for Rotavirus vaccination.
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