Author: Tromas, Nicolas; Zwart, Mark P.; Forment, Javier; Elena, Santiago F.
Title: Shrinkage of Genome Size in a Plant RNA Virus upon Transfer of an Essential Viral Gene into the Host Genome Document date: 2014_2_20
ID: 5fejitls_43
Snippet: TEV is translated into a large polyprotein, thus the cleavage process may be a mechanism to regulate the effective concentration of viral proteins in infected cells (Merits et al. 2002) . Most of these mutations analyzed in this section showed a significant higher viral accumulation than the ancestral genotype. The mutations we found in evolved lineages may positively regulate the cleavage 6K1/CI in order to produce more mature 6K1 and CI protein.....
Document: TEV is translated into a large polyprotein, thus the cleavage process may be a mechanism to regulate the effective concentration of viral proteins in infected cells (Merits et al. 2002) . Most of these mutations analyzed in this section showed a significant higher viral accumulation than the ancestral genotype. The mutations we found in evolved lineages may positively regulate the cleavage 6K1/CI in order to produce more mature 6K1 and CI proteins. NIb and CI are constituents of the viral replication complex (Li et al. 1997) , and thus increasing the effective CI concentration may counterbalance the lower production of NIb from the transgene.
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