Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness

Lee, Yong-ho; Kim, Jae Hyeon; Kim, So Ra; Jin, Heung Yong; Rhee, Eun-Jung; Cho, Young Min; Lee, Byung-Wan

All continuous variables were expressed as the mean ± standard deviation (SD). The AST, ALT, and TG values were log transformed, because value distributions were skewed. Student's t-tests and Pearson's χ 2 tests were used for continuous and categorical variables, respectively, to evaluate any differences according to lobeglitazone responsiveness. A responder to lobeglitazone was defined as any individual who showed a decrease in CAP after treatment. Changes in clinico-laboratory parameters, including CAP and HbA1C values, after lobeglitazone treatment were evaluated using a paired t-test. We performed correlation analyses to examine the relationship between changes in CAP values and clinico-laboratory parameters at baseline and after treatment. Multivariate linear regression analysis was performed to assess the association between CAP value changes and various clinico-laboratory parameters. The results are expressed as values of standardized (STD) β-coefficients and P values. A twosided P value < 0.05 was considered significant. All statistical analyses were conducted using SPSS for Windows software (version 20.0; SPSS Inc., Chicago, IL, USA).