Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness

Lee, Yong-ho; Kim, Jae Hyeon; Kim, So Ra; Jin, Heung Yong; Rhee, Eun-Jung; Cho, Young Min; Lee, Byung-Wan

We used the right lobe of the liver through intercostal space to obtain CAP values and liver stiffness measurements (LSM), as described previously (18) . For the CAP assessment, we used a Fibroscan 501 ® (Echosens), placing the tip of the M probe on the skin between the ribs, over the right lobe of the liver. To ensure https://doi.org/10.3346/jkms.2017.32.1.60 an accurate CAP value, we only calculated US attenuation when the matched LSM was valid, while attempting to collect ≥ 10 valid LSMs. A success rate of ≥ 60% and a ratio for the interquartile range (IQR) to the median value of LSM (IQR/MLSM) of ≤ 30% were considered reliable and used for the final analysis. CAP values were measured by a trained operator following the manufacturer's instruction. The steatosis grade (S) was determined using the following CAP-cutoff values that were previously reported by Sasso et al. (11) : 238 dB/m for S ≥ 1, 260 dB/m for S ≥ 2, and 293 dB/m for S = 3. US scanning was performed by professional radiologists. Because US was not performed to investigate the study endpoint and merely used to rule out other liver disorders, the US methods and devices were not standardized.