Selected article for: "cytokine production and DCreg expression"
Author: Su, Xiaoping; Qian, Cheng; Zhang, Qian; Hou, Jin; Gu, Yan; Han, Yanmei; Chen, Yongjian; Jiang, Minghong; Cao, Xuetao
Title: miRNomes of haematopoietic stem cells and dendritic cells identify miR-30b as a regulator of Notch1
  • Document date: 2013_12_6
    • ID: 4vo7n6nh_26_1
    Snippet: response, such as modulation of cytokine production, its roles in regulating miRNA expression remain unknown. Here we showed that the enriched expression of miR-30b in DCreg was dependent on TGF-b/Smad3 signaling, and more Smad3 binding to the acetylated promoter region of miR-30b in DCreg. These data have suggested a new model of gene expression regulation mediated by activated TGF-b/Smad3 signaling, which may present indications in researching .....
    Document: response, such as modulation of cytokine production, its roles in regulating miRNA expression remain unknown. Here we showed that the enriched expression of miR-30b in DCreg was dependent on TGF-b/Smad3 signaling, and more Smad3 binding to the acetylated promoter region of miR-30b in DCreg. These data have suggested a new model of gene expression regulation mediated by activated TGF-b/Smad3 signaling, which may present indications in researching the mechanisms of TGF-b regulating immune response.

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