Author: Wang, Yanli; Addess, Kenneth J.; Chen, Jie; Geer, Lewis Y.; He, Jane; He, Siqian; Lu, Shennan; Madej, Thomas; Marchler-Bauer, Aron; Thiessen, Paul A.; Zhang, Naigong; Bryant, Stephen H.
Title: MMDB: annotating protein sequences with Entrez's 3D-structure database Document date: 2006_11_29
ID: 6qpsxmgi_11
Snippet: One may further identify the catalytic center by identifying residues that contact the catalytic Zinc ion. Those sites can then be mapped from the structure to aligned regions in the sequence window using Cn3D's highlighting functionality. One may also examine the sequence-structure alignments with related structures 1UZE and 1UZF, human ACE binding to enalaprilat and captopril, respectively, drugs with chemical structures similar to that of lisi.....
Document: One may further identify the catalytic center by identifying residues that contact the catalytic Zinc ion. Those sites can then be mapped from the structure to aligned regions in the sequence window using Cn3D's highlighting functionality. One may also examine the sequence-structure alignments with related structures 1UZE and 1UZF, human ACE binding to enalaprilat and captopril, respectively, drugs with chemical structures similar to that of lisinopril. This allows one to identify conserved interactions between the ACE enzyme and this series of antihypertensive drugs. Similarly, by examining the related structure 2AJF (13), one may be able to identify residues critical for cross-species infection by studying the protein-protein interactions between the receptor binding domain from SARS Coronavirus Spike and human versus rat angiotensin-converting enzyme 2.
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