Author: Moody, M. Anthony
Title: Modulation of HIV-1 immunity by adjuvants Document date: 2014_4_10
ID: 1nm1tbig_10
Snippet: DNA vaccines are attractive for eliciting CD8 þ T-cell responses, as protein production and antigen processing can occur without the need for an infectious vector. DNA vaccines are generally not as potent at eliciting antibody responses, although evidence suggests that DNA vaccines can prime for subsequent protein boosts [7, 8] . Numerous studies have reported the ability of immune modulators to provide an adjuvant effect for DNA vaccines [36] [.....
Document: DNA vaccines are attractive for eliciting CD8 þ T-cell responses, as protein production and antigen processing can occur without the need for an infectious vector. DNA vaccines are generally not as potent at eliciting antibody responses, although evidence suggests that DNA vaccines can prime for subsequent protein boosts [7, 8] . Numerous studies have reported the ability of immune modulators to provide an adjuvant effect for DNA vaccines [36] [37] [38] [39] [40] [41] [42] [43] [44] [45] [46] [47] [48] [49] ; most of these studies were performed in mice and few compared more than one regimen against an unadjuvanted control. There are no studies
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