Author: Moody, M. Anthony
Title: Modulation of HIV-1 immunity by adjuvants Document date: 2014_4_10
ID: 1nm1tbig_16
Snippet: Some studies have examined the effect of adding compounds to DNA vaccines without having them encoded in a vector. Mycobacterial extracts have been shown to enhance T-cell and antibody responses in mice [51] as have TLR9 agonists [52] . Liposomes with mannan as a delivery vehicle for a DNA vaccine enhanced fecal IgA responses and altered subclass responses in mice [53] . Another Toll-like receptor (TLR) agonist, imiquimod, applied topically adjuv.....
Document: Some studies have examined the effect of adding compounds to DNA vaccines without having them encoded in a vector. Mycobacterial extracts have been shown to enhance T-cell and antibody responses in mice [51] as have TLR9 agonists [52] . Liposomes with mannan as a delivery vehicle for a DNA vaccine enhanced fecal IgA responses and altered subclass responses in mice [53] . Another Toll-like receptor (TLR) agonist, imiquimod, applied topically adjuvanted a DNA vaccine in mice, although the effect was similar to that of GM-CSF [54] . As with DNA-encoded adjuvant molecules, it is unclear which of these strategies is superior.
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