Author: Kammer, Andreas R.; van der Burg, Sjoerd H.; Grabscheid, Benno; Hunziker, Isabelle P.; Kwappenberg, Kitty M.C.; Reichen, Jürg; Melief, Cornelis J.M.; Cerny, Andreas
Title: Molecular Mimicry of Human Cytochrome P450 by Hepatitis C Virus at the Level of Cytotoxic T Cell Recognition Document date: 1999_7_19
ID: 1vabzhs5_3
Snippet: To determine the relevance of the sequence similarities between an HCV-derived CTL epitope and members of the CYP family for pathogenesis of HCV-associated autoimmune hepatitis, we analyzed the primary CTL repertoire, inducing primary CTL responses in the PBMCs of HCVnegative, healthy blood donors as well as those of patients with chronic HCV infection without markers for AIH. For induction, we used the HCV core 178 epitope as well as both CYP-de.....
Document: To determine the relevance of the sequence similarities between an HCV-derived CTL epitope and members of the CYP family for pathogenesis of HCV-associated autoimmune hepatitis, we analyzed the primary CTL repertoire, inducing primary CTL responses in the PBMCs of HCVnegative, healthy blood donors as well as those of patients with chronic HCV infection without markers for AIH. For induction, we used the HCV core 178 epitope as well as both CYP-derived peptides. CTL were then tested for their ability to recognize all three different peptide ligands.
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