Author: Pipirou, Zoi; Powlesland, Alex S; Steffen, Imke; Pöhlmann, Stefan; Taylor, Maureen E; Drickamer, Kurt
Title: Mouse LSECtin as a model for a human Ebola virus receptor Document date: 2011_1_21
ID: 41i20yuy_17
Snippet: The similarity in the binding specificities of human and mouse LSECtin suggested that, like the human protein, mouse LSECtin might be a target for binding to the surface glycoprotein of Ebola virus. The Ebola glycoprotein has been shown to bear an unusually large number of under-processed glycans with terminal GlcNAcβ1-2Man that are not further modified by addition of galactose (Powlesland et al. 2008) . A direct binding assay confirmed that hum.....
Document: The similarity in the binding specificities of human and mouse LSECtin suggested that, like the human protein, mouse LSECtin might be a target for binding to the surface glycoprotein of Ebola virus. The Ebola glycoprotein has been shown to bear an unusually large number of under-processed glycans with terminal GlcNAcβ1-2Man that are not further modified by addition of galactose (Powlesland et al. 2008) . A direct binding assay confirmed that human and mouse LSECtin interact with the Ebola glycoprotein-Fc fusion protein with very similar affinities of 0.52 µg mL −1 for the mouse protein and 0.48 µg mL −1 for the human protein ( Figure 5 ). This result provides important evidence that the mouse protein is a potentially useful model for human Ebola virus interaction with human sinusoidal endothelial cells.
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