Author: White, Crystal; Mortier, Jeremy; Verin, Ranieri; Maddox, Thomas; Goncalves, Rita; Sanchez-Masian, Daniel
Title: MRI findings of neuronal ceroid lipofuscinosis in a cat Document date: 2018_3_5
ID: 0gzef0ae_9
Snippet: Meninges showed diffuse moderate thickening due to deposition of palely eosinophilic mature collagen interpreted as fibrosis and confirmed with Masson's trichrome stain. All cerebral areas examined showed mildto-moderate gliosis and moderate loss of neurons (more severe in cortical areas) with numerous neurons distended and enlarged by botryoid, palely acidophilic to glassy cytoplasmic inclusions (Figure 3b (Figure 3i ), consistent morphologicall.....
Document: Meninges showed diffuse moderate thickening due to deposition of palely eosinophilic mature collagen interpreted as fibrosis and confirmed with Masson's trichrome stain. All cerebral areas examined showed mildto-moderate gliosis and moderate loss of neurons (more severe in cortical areas) with numerous neurons distended and enlarged by botryoid, palely acidophilic to glassy cytoplasmic inclusions (Figure 3b (Figure 3i ), consistent morphologically with previously described intra-neuronal lipofuscins in cats. [1] [2] [3] [4] No further gross and histopathological changes were observed in the main thoracic and abdominal organs, including autonomic ganglia. Furthermore, both eyes were thoroughly examined to rule out the presence of retinal neuronal inclusions and to confirm the suspect of central blindness. Neither eye showed histopathological changes.
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