Author: Yu, Xiaobo; Song, Lusheng; Petritis, Brianne; Bian, Xiaofang; Wang, Haoyu; Viloria, Jennifer; Park, Jin; Bui, Hoang; Li, Han; Wang, Jie; Liu, Lei; Yang, Liuhui; Duan, Hu; McMurray, David N.; Achkar, Jacqueline M.; Magee, Mitch; Qiu, Ji; LaBaer, Joshua
Title: Multiplexed Nucleic Acid Programmable Protein Arrays Document date: 2017_9_20
ID: 7t1o19kn_12
Snippet: The total number of printed spots (N) needed for the combined two-round screening of 10k proteins was determined by the number of plasmids printed per spot and the anticipated hit rates (i.e., percentage of displayed proteins that will be identified as significant in the study). The probability p of an individual protein being a true hit can be estimated from previous studies of a similar nature (e.g., antibody biomarkers). The following equation.....
Document: The total number of printed spots (N) needed for the combined two-round screening of 10k proteins was determined by the number of plasmids printed per spot and the anticipated hit rates (i.e., percentage of displayed proteins that will be identified as significant in the study). The probability p of an individual protein being a true hit can be estimated from previous studies of a similar nature (e.g., antibody biomarkers). The following equation assumes that p follows a Bernoulli distribution and that its corresponding plasmid is randomly multiplexed where the number of different plasmids per spot is k:
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