Author: Daniels, Keith A.; Devora, Gene; Lai, Wayne C.; O'Donnell, Carey L.; Bennett, Michael; Welsh, Raymond M.
Title: Murine Cytomegalovirus Is Regulated by a Discrete Subset of Natural Killer Cells Reactive with Monoclonal Antibody to Ly49h Document date: 2001_7_2
ID: 6n3dmle6_3
Snippet: NK cells regulate MCMV infection by different preferred mechanisms in different organs. In the liver, MCMV is controlled by IFN-⥠, possibly acting through a nitric oxide synthase intermediate (18, 19) . The chemokine MIP-1 ⣠attracts NK cells into the liver (20) . MCMV induces relatively high levels of IL-12, which serves to induce secretion of IFN-⥠from the highly activated NK cells (18) . In the spleen, the NK cell-mediated control of M.....
Document: NK cells regulate MCMV infection by different preferred mechanisms in different organs. In the liver, MCMV is controlled by IFN-⥠, possibly acting through a nitric oxide synthase intermediate (18, 19) . The chemokine MIP-1 ⣠attracts NK cells into the liver (20) . MCMV induces relatively high levels of IL-12, which serves to induce secretion of IFN-⥠from the highly activated NK cells (18) . In the spleen, the NK cell-mediated control of MCMV is less dependent on IFN-⥠and more dependent on perforin (19) . The presumption is that a cytotoxic mechanism regulates MCMV in the spleen, but it is not known why these organs differ mechanistically in their control of MCMV. Of note is that the Cmv-1 locus appears to regulate MCMV synthesis more in the spleen than in the liver, suggesting that it might relate to a cytotoxic mechanism (7) .
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