Author: Daniels, Keith A.; Devora, Gene; Lai, Wayne C.; O'Donnell, Carey L.; Bennett, Michael; Welsh, Raymond M.
Title: Murine Cytomegalovirus Is Regulated by a Discrete Subset of Natural Killer Cells Reactive with Monoclonal Antibody to Ly49h Document date: 2001_7_2
ID: 6n3dmle6_33
Snippet: Livers from mAb 1F8-treated mice displayed a greater number of white necrotic foci on their surfaces, which is characteristic of severe MCMV infection. Fig. 8 shows liver sections from infected control (A and B) or mAb 1F8treated (C and D) mice. MCMV-infected control mice tended to have mostly discrete small inflammatory infiltrates around hepatocytes displaying pyknotic nuclei and cell-rounding characteristic of MCMV infection (Fig. 8, A and B .....
Document: Livers from mAb 1F8-treated mice displayed a greater number of white necrotic foci on their surfaces, which is characteristic of severe MCMV infection. Fig. 8 shows liver sections from infected control (A and B) or mAb 1F8treated (C and D) mice. MCMV-infected control mice tended to have mostly discrete small inflammatory infiltrates around hepatocytes displaying pyknotic nuclei and cell-rounding characteristic of MCMV infection (Fig. 8, A and B ). In contrast, large areas of necrosis, particularly near the surface of the liver and easily distinguished by the naked eye, were characteristic of the MCMV infection in mAb 1F8-treated mice (Fig. 8, C and D) . Similar increases in pathology have been reported in mice depleted of NK cells with pan NK cell reagents (14, 36) .
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