Author: Chattopadhyay, Saborni; Chen, Jui-Yi; Chen, Hui-Wen; Hu, Che-Ming Jack
Title: Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation Document date: 2017_6_9
ID: 7q2wkwrf_24
Snippet: Silica nanoparticles offer a range of particle sizes and shapes via controlled synthesis using sol-gel chemistry. An abundance of silanol groups on silica nanoparticle surface allow for functional modifications for increasing specific cellular recognition, facilitating attachment of specific biomolecules, and modulating cellular uptake [109] [110] [111] . Nanoscale pores can be integrated into silica nanoparticles, yielding mesoporous silica nano.....
Document: Silica nanoparticles offer a range of particle sizes and shapes via controlled synthesis using sol-gel chemistry. An abundance of silanol groups on silica nanoparticle surface allow for functional modifications for increasing specific cellular recognition, facilitating attachment of specific biomolecules, and modulating cellular uptake [109] [110] [111] . Nanoscale pores can be integrated into silica nanoparticles, yielding mesoporous silica nanoparticles (MSNs) with more versatile cargo-carrying capacity for vaccination purposes [112, 113] . The pore size and surface functionalization of MSNs can be modified to control the encapsulation and release of antigens or adjuvants of choice [114] [115] [116] [117] . Use of silica nanoparticles in vaccine applications include formulations against snake venom, E. coli [118] , porcine circovirus [119] , HIV [120] , and other model antigens [121] .
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