Author: William Binning; Aja E. Hogan-Cann; Diana Yae Sakae; Matthew Maksoud; Valeriy Ostapchenko; Mohammed Al-Onaizi; Sara Matovic; Wei-Yang Lu; Marco A. M. Prado; Wataru Inoue; Vania F. Prado
Title: Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice Document date: 2020_1_28
ID: ely200x3_90
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi. org/10.1101 org/10. /2020 We also investigated whether activation of hM3Dq with CNO alters social behaviors. The three-chamber social preference task showed that hM3Dq signaling in microglia does not change sociability, as time spent investigating another rodent as compared to time spent investigating a plastic block was similar between CNO-and vehicle-trea.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi. org/10.1101 org/10. /2020 We also investigated whether activation of hM3Dq with CNO alters social behaviors. The three-chamber social preference task showed that hM3Dq signaling in microglia does not change sociability, as time spent investigating another rodent as compared to time spent investigating a plastic block was similar between CNO-and vehicle-treated CX3CR1CreER(+/-)-hM3Dq(+/-) mice F(4,56)=1.156, p=0.3403) . These results suggest that, within the parameters we used, activation of hM3Dq in microglia does not affect normal mouse behavior.
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