Author: Groeneveld, Geert H; van der Reyden, Tanny J; Joosten, Simone A; Bootsma, Hester J; Cobbaert, Christa M; de Vries, Jutte J C; Kuijper, Ed J; van Dissel, Jaap T
Title: Non-lytic antibiotic treatment in community-acquired pneumococcal pneumonia does not attenuate inflammation: the PRISTINE trial Document date: 2019_5_18
ID: 19ueli6e_60
Snippet: Strategies to dampen the inflammatory response in pneumonia have so far primarily focused on corticosteroids. Corticosteroid therapy has been demonstrated to result in shorter times to clinical stability and limited shortening of hospital stays in patients with non-severe community-acquired pneumonia. Some studies in adults with severe disease have shown a reduction in mortality. The quality of these studies is moderate. In all studies, corticost.....
Document: Strategies to dampen the inflammatory response in pneumonia have so far primarily focused on corticosteroids. Corticosteroid therapy has been demonstrated to result in shorter times to clinical stability and limited shortening of hospital stays in patients with non-severe community-acquired pneumonia. Some studies in adults with severe disease have shown a reduction in mortality. The quality of these studies is moderate. In all studies, corticosteroid therapy increased the risk of hyperglycemia. 38 Therefore, corticosteroids are not included in current treatment guidelines. 7, 8 Alternative therapeutic options should be explored to attenuate the inflammation.
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