Author: Joseph, Patrick; Godofsky, Eliot
Title: Outpatient Antibiotic Stewardship: A Growing Frontier—Combining Myxovirus Resistance Protein A With Other Biomarkers to Improve Antibiotic Use Document date: 2018_2_15
ID: 0emio4rl_12
Snippet: When Group A strep is cultured from the OP and associated with an antibody response characteristic of a true infection, CRP will elevate 80%-90% of the time [15, 17] . Conversely, patients with a negative initial CRP test seldom show a rise in antibody titer [19] , and 96% have CRP <10 mg/mL [20] . The high carrier rate of GABHS and false-positive diagnoses may contribute to the apparent "failure" rate of approximately 20% with penicillin therapy.....
Document: When Group A strep is cultured from the OP and associated with an antibody response characteristic of a true infection, CRP will elevate 80%-90% of the time [15, 17] . Conversely, patients with a negative initial CRP test seldom show a rise in antibody titer [19] , and 96% have CRP <10 mg/mL [20] . The high carrier rate of GABHS and false-positive diagnoses may contribute to the apparent "failure" rate of approximately 20% with penicillin therapy [21] . Valkenburg et al. have shown that an antistreptococcal antibody titer is more accurate than a throat culture in predicting therapeutic outcome [22] .
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