Overexpression of Tripartite Motif Conaining 55 (TRIM55) Inhibits Migration and Invasion of Hepatocellular Carcinoma (HCC) Cells via Epithelial-Mesenchymal Transition and Matrix Metalloproteinase-2 (MMP2)

Li, Xinyu; Huang, Lei; Gao, Weijie

We first detected expression of TRIM55 in 100 paired HCC tissues and adjacent-normal tissues and found TRIM55 was underexpressed in HCC tissues. Kaplan-Meier analysis showed that low expression of TRIM55 was always associated with poor overall survival time, and Cox regression analysis also verified that TRIM55 was an independent predictive factor in HCC patients. To investigate the function of TRIM55 in HCC cells, we analyzed the relationship between expression of TRIM55 and clinicopathologic features, and found that TRIM55 was correlated with tumor vessel invasion. Then, we used Transwell assay to verify this, and the results showed that overexpression of TRIM55 leads to lower migration and invasion ability of HCC cells. Thus, we preliminary demonstrated that TRIM55 is involved in metastasis of HCC cells.