Author: Rao, Xiaoquan; Zhao, Shi; Braunstein, Zachary; Mao, Hong; Razavi, Michael; Duan, Lihua; Wei, Yingying; Toomey, Amelia C.; Rajagopalan, Sanjay; Zhong, Jixin
Title: Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways Document date: 2019_2_7
ID: 1n7xjjd5_14
Snippet: In the current study, we identified that CD36/TLR4/TRIF inflammatory pathways are responsible for the upregulation of monocyte/macrophage DPP4 in obesity/atherosclerosis. These findings demonstrated an important role for oxidized lipids in immune cell DPP4 regulation and may provide an integrated mechanism linking abnormal post-prandial glucose metabolism with oxidized lipids and inflammation......
Document: In the current study, we identified that CD36/TLR4/TRIF inflammatory pathways are responsible for the upregulation of monocyte/macrophage DPP4 in obesity/atherosclerosis. These findings demonstrated an important role for oxidized lipids in immune cell DPP4 regulation and may provide an integrated mechanism linking abnormal post-prandial glucose metabolism with oxidized lipids and inflammation.
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