Author: Qiao, Hui; Pelletier, Sandra L.; Hoffman, Lucas; Hacker, Jill; Armstrong, R. Todd; White, Judith M.
Title: Specific Single or Double Proline Substitutions in the “Spring-loaded” Coiled-Coil Region of the Influenza Hemagglutinin Impair or Abolish Membrane Fusion Activity Document date: 1998_6_15
ID: 78fjem8s_43
Snippet: As seen in Fig. 5 A, and mirroring their behavior in the proteinase K assay (Fig. 4 A) , the Ala mutants acquired reactivity with the C-HA1 antibody with either the same (V55A, S71A) or with an elevated (L80A) pH dependence compared with wt-HA. S71P also behaved like wt-HA (Fig. 5 B) . V55P showed ‫%05Ù‬ reactivity with C-HA1 at pH 7 and an elevated and less well-defined pH profile for antibody reactivity. L80P was fully reactive with the C-.....
Document: As seen in Fig. 5 A, and mirroring their behavior in the proteinase K assay (Fig. 4 A) , the Ala mutants acquired reactivity with the C-HA1 antibody with either the same (V55A, S71A) or with an elevated (L80A) pH dependence compared with wt-HA. S71P also behaved like wt-HA (Fig. 5 B) . V55P showed ‫%05Ù‬ reactivity with C-HA1 at pH 7 and an elevated and less well-defined pH profile for antibody reactivity. L80P was fully reactive with the C-HA1 antibody over the entire pH range tested.
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