Selected article for: "mononuclear cell and peripheral blood"
Author: Srivastava, Sukrit; Kamthania, Mohit; Singh, Soni; Saxena, Ajay K; Sharma, Nishi
Title: Structural basis of development of multi-epitope vaccine against Middle East respiratory syndrome using in silico approach
  • Document date: 2018_11_21
    • ID: 33h22ikl_36
    Snippet: screening of hTl epitopes Screening of HTL epitopes was performed on the basis of "percentile rank". Small percentile rank shows the high affinity of the peptide for its respective HLA allele. Initially, from the 13 MERS-CoV proteins, 70 CD4+ T-cell epitopes with the highest percentile rank were screened, and 28 epitopes with high percentile rank and the highest number of HLA class II allele binders were then shortlisted (Tables S5 and S6 ). Sev.....
    Document: screening of hTl epitopes Screening of HTL epitopes was performed on the basis of "percentile rank". Small percentile rank shows the high affinity of the peptide for its respective HLA allele. Initially, from the 13 MERS-CoV proteins, 70 CD4+ T-cell epitopes with the highest percentile rank were screened, and 28 epitopes with high percentile rank and the highest number of HLA class II allele binders were then shortlisted (Tables S5 and S6 ). Several CTL and HTL epitopes predicted in the present study show overlapping regions with the epitopes detected to induce T-cell responses in previous studies done using peripheral blood mononuclear cells from infected patients. 68 Hence, epitopes screened and reported in the present study could be predicted to originate from the highly immunogenic stretch of MERS-CoV protein sequences.

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