Selected article for: "positive strand and virus positive strand"
Author: Mateo, Roberto; Nagamine, Claude M.; Kirkegaard, Karla
Title: Suppression of Drug Resistance in Dengue Virus
  • Document date: 2015_12_15
    • ID: 6bx2nrui_2
    Snippet: The only positive-strand RNA virus for which effective pharmacological treatment exists is hepatitis C virus (HCV), which serves as an illustration of the current paradigm for successful antiviral development. Anti-HCV drugs that target the NS3/4 protease, the NS5A nonstructural protein, and the NS5B polymerase are currently available. The high cost of these drugs, with individual treatments averaging $80,000 per patient, has contributed to a 13%.....
    Document: The only positive-strand RNA virus for which effective pharmacological treatment exists is hepatitis C virus (HCV), which serves as an illustration of the current paradigm for successful antiviral development. Anti-HCV drugs that target the NS3/4 protease, the NS5A nonstructural protein, and the NS5B polymerase are currently available. The high cost of these drugs, with individual treatments averaging $80,000 per patient, has contributed to a 13% increase in prescription drug spending in the United States alone since 2013 (4) (5) (6) . This paradigm is not sustainable for the many infections that threaten human health and productivity worldwide.

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