Author: William Binning; Aja E. Hogan-Cann; Diana Yae Sakae; Matthew Maksoud; Valeriy Ostapchenko; Mohammed Al-Onaizi; Sara Matovic; Wei-Yang Lu; Marco A. M. Prado; Wataru Inoue; Vania F. Prado
Title: Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice Document date: 2020_1_28
ID: ely200x3_98
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.01.27.921809 doi: bioRxiv preprint days, challenged them with LPS (0.1 mg/kg, i.p.) on the 4th day and then performed different behavioral tests 2 h and 24 h after LPS administration (Fig. 6A) . As control groups we used CX3CR1CreER(+/-)-hM3Dq(+/-) mice that received vehicle instead of CNO. Weight analysis during the 5 days showed that activ.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.01.27.921809 doi: bioRxiv preprint days, challenged them with LPS (0.1 mg/kg, i.p.) on the 4th day and then performed different behavioral tests 2 h and 24 h after LPS administration (Fig. 6A) . As control groups we used CX3CR1CreER(+/-)-hM3Dq(+/-) mice that received vehicle instead of CNO. Weight analysis during the 5 days showed that activation of hM3Dq with CNO alone did not lead to significant change in weight. On the other hand, both CNO-and vehicle-treated mice showed significant weight loss after LPS injection ( Fig. 6B ; time: F(4,80)=51.43, p<0.0001, two-way ANOVA repeated measures).
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