Author: Sun, Shihui; Jiang, Yuting; Wang, Renxi; Liu, Chenfeng; Liu, Xiaoling; Song, Nianping; Guo, Yan; Guo, Renfeng; Du, Lanying; Jiang, Shibo; Li, Yan; Qiu, Zewu; Zhao, Guangyu; Zhou, Yusen
Title: Treatment of Paraquat-Induced Lung Injury With an Anti-C5a Antibody: Potential Clinical Application* Document date: 2018_4_13
ID: 6ztwho9k_7
Snippet: IFX-1 (NCT01319903; developed by InflaRx GmbH, Jena, Germany), a highly potent neutralizing antihuman C5a monoclonal antibody that leaves the formation of the membrane attack complex (MAC), is in various phase II clinical trials (www.inflarx.de). In this study, we tested whether IFX-1 is an effective way to alleviate ALI by blocking systemic inflammatory responses in a monkey model of paraquat poisoning. The results showed that IFX-1 alleviated A.....
Document: IFX-1 (NCT01319903; developed by InflaRx GmbH, Jena, Germany), a highly potent neutralizing antihuman C5a monoclonal antibody that leaves the formation of the membrane attack complex (MAC), is in various phase II clinical trials (www.inflarx.de). In this study, we tested whether IFX-1 is an effective way to alleviate ALI by blocking systemic inflammatory responses in a monkey model of paraquat poisoning. The results showed that IFX-1 alleviated ALI and reduced levels of systemic inflammation. Importantly, in vitro data indicated that IFX-1 effectively blocks granulocytes activation by plasma from paraquat patients. Thus, targeting C5a might be a promising strategy for adjunctive treatment of ALI induced by toxic agents, such as paraquat.
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