Selected article for: "cell surface and functional receptor"
Title: Triggering through CD16 or phorbol esters enhances adhesion of NK cells to laminin via very late antigen 6
  • Document date: 1992_11_1
    • ID: 3ymo8zw0_2
    Snippet: Laminin (LM) is a member of an expanding family of multidomain ECM glycoproteins and one of the major basement membrane components (6) . Most cell-surface LM receptors belong to the integrin superfamily (7) . In the (31 integrin family, four heterodimers have been implicated as LM 1 Abbreviations used in this paper: ECM, extracellular matrix ; LGL, large granular lymphocytes ; LM, laminin ; LMR, laminin receptors ; TPA, 12-O-tetradecanoylphorbol-.....
    Document: Laminin (LM) is a member of an expanding family of multidomain ECM glycoproteins and one of the major basement membrane components (6) . Most cell-surface LM receptors belong to the integrin superfamily (7) . In the (31 integrin family, four heterodimers have been implicated as LM 1 Abbreviations used in this paper: ECM, extracellular matrix ; LGL, large granular lymphocytes ; LM, laminin ; LMR, laminin receptors ; TPA, 12-O-tetradecanoylphorbol-13-acetate . 1251 receptors : a101(VLA-1) ; u201(VLA-2) ; a301(VLA-3) ; and x6(31 (VLA-6) (8) . The more specific LM receptor is VLA-6, which was first identified on platelets (9) , but it is also present on monocytes, lymphocytes, and thymocytes (8) . Among the LM-binding integrins expressed on leukocytes, only VLA-6 appears to be a functional receptor, and its avidity is rapidly enhanced by short-term cell activation (10, 11) .

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