Author: Heaton, Steven M.; Borg, Natalie A.; Dixit, Vishva M.
Title: Ubiquitin in the activation and attenuation of innate antiviral immunity Document date: 2016_1_11
ID: 42d77vxf_32
Snippet: Another mitochondrial link between the NLR and RLR signaling pathways is the ubiquitously expressed NLRX1 (Fig. 2, right) , whose role in IFN-I regulation is controversial. NLRX1 is localized to the mitochondrial outer membrane and was reported to inhibit MAVS-dependent IFN-I signaling by blocking the interaction between activated RIG-I/MDA5 and MAVS, although viral replication experiments using gene knockout cells have produced conflicting resul.....
Document: Another mitochondrial link between the NLR and RLR signaling pathways is the ubiquitously expressed NLRX1 (Fig. 2, right) , whose role in IFN-I regulation is controversial. NLRX1 is localized to the mitochondrial outer membrane and was reported to inhibit MAVS-dependent IFN-I signaling by blocking the interaction between activated RIG-I/MDA5 and MAVS, although viral replication experiments using gene knockout cells have produced conflicting results (Soares et al., 2013) . NLRX1 also potentiates NF-κB signaling by promoting reactive oxygen species production during bacterial infection, linking the mitochondrial immune signaling platform with proinflammatory cytokine generation (Tattoli et al., 2008) .
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