Author: Janice Oh, Hsueh-Ling; Ken-En Gan, Samuel; Bertoletti, Antonio; Tan, Yee-Joo
Title: Understanding the T cell immune response in SARS coronavirus infection Document date: 2012_9_5
ID: 5uoepd0r_7
Snippet: Animal studies using mice primed intramuscularly with S DNA vaccine and boosted with subcutaneous HLA-A*02:01 restricted peptides 25 or with the S DNA vaccine alone 26 elicited antigen-specific CD8 1 T cell responses. In fact, one recent study showed that primeboost immunization of transgenic mice with 5 of the HLA-A*02:01 S peptides together with CpG oligodeoxynucleotide (ODN) could significantly enhance the frequency of peptide-specific CD8 1 T.....
Document: Animal studies using mice primed intramuscularly with S DNA vaccine and boosted with subcutaneous HLA-A*02:01 restricted peptides 25 or with the S DNA vaccine alone 26 elicited antigen-specific CD8 1 T cell responses. In fact, one recent study showed that primeboost immunization of transgenic mice with 5 of the HLA-A*02:01 S peptides together with CpG oligodeoxynucleotide (ODN) could significantly enhance the frequency of peptide-specific CD8 1 T cells. 27 Taken together, the S protein is not only capable of inducing neutralizing antibodies but also contains several immunogenic T cell epitopes. Some of these epitopes found in either the S1 or S2 domain of the protein should therefore be considered during SARS-CoV vaccine development.
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