Author: Welch, Matthew D.
Title: Why should cell biologists study microbial pathogens? Document date: 2015_12_1
ID: 04xyhhmf_5
Snippet: In this Perspective, I provide concrete answers to the basic question posed in the title: Why should cell biologists study microbial pathogens? Along the way, I explore three smaller questions: What have we learned about basic cell biology from studying pathogens and their virulence factors? What has studying the cell biology of host-pathogen interactions taught us about immunity? How has Monitoring Editor Doug Kellogg University of California, S.....
Document: In this Perspective, I provide concrete answers to the basic question posed in the title: Why should cell biologists study microbial pathogens? Along the way, I explore three smaller questions: What have we learned about basic cell biology from studying pathogens and their virulence factors? What has studying the cell biology of host-pathogen interactions taught us about immunity? How has Monitoring Editor Doug Kellogg University of California, Santa Cruz inhibit phagocytosis by producing virulence factors that disable Rho, Rac, and/or Cdc42, highlighting the generality of this pathogenic strategy (Lemichez and Aktories, 2013) . Bacterial toxins continue to be important tools for revealing the functions of Rho GTPases in cells.
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