Selected article for: "fat accumulation and hepatic fat accumulation"
Author: Baumeier, Christian; Schlüter, Luisa; Saussenthaler, Sophie; Laeger, Thomas; Rödiger, Maria; Alaze, Stella Amelie; Fritsche, Louise; Häring, Hans-Ulrich; Stefan, Norbert; Fritsche, Andreas; Schwenk, Robert Wolfgang; Schürmann, Annette
Title: Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease
  • Document date: 2017_8_4
    • ID: 64az0pco_32
    Snippet: Collectively, the present study shows that hepatic DPP4 is an important contributor to the development of NAFLD under conditions of high-fat feeding. Overexpressing Dpp4 specifically in hepatocytes of mice resulted in hepatic insulin resistance and pronounced liver steatosis. This finding demonstrates that DPP4 is involved in the regulation of hepatic insulin sensitivity and subsequently lipid storage and not solely a marker of the disease. Based.....
    Document: Collectively, the present study shows that hepatic DPP4 is an important contributor to the development of NAFLD under conditions of high-fat feeding. Overexpressing Dpp4 specifically in hepatocytes of mice resulted in hepatic insulin resistance and pronounced liver steatosis. This finding demonstrates that DPP4 is involved in the regulation of hepatic insulin sensitivity and subsequently lipid storage and not solely a marker of the disease. Based on our findings, we propose the application of DPP4 inhibitors in the therapy of NAFLD patients in order to improve hepatic insulin sensitivity and to prevent further accumulation of ectopic fat in the liver.

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