Author: Dong, Xiaoxv; Ni, Boran; Fu, Jing; Yin, Xingbin; You, Longtai; Leng, Xin; Liang, Xiao; Ni, Jian
Title: Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase-dependent pathway Document date: 2018_8_2
ID: 02r8i5n1_17
Snippet: Emodin induces the apoptosis of HepaRG cells. Annexin V-FITC/PI double staining was performed to quantify emodin-induced apoptosis. The percentage of viable cells was significantly decreased after treatment with emodin for 24 h. Furthermore, both the early and late apoptotic cell populations increased 7.5-and 8.3-fold in the HepaRG cells, respectively. However, pretreatment with NAC successfully reversed the apoptosis induction ( Fig. 3A and B) ......
Document: Emodin induces the apoptosis of HepaRG cells. Annexin V-FITC/PI double staining was performed to quantify emodin-induced apoptosis. The percentage of viable cells was significantly decreased after treatment with emodin for 24 h. Furthermore, both the early and late apoptotic cell populations increased 7.5-and 8.3-fold in the HepaRG cells, respectively. However, pretreatment with NAC successfully reversed the apoptosis induction ( Fig. 3A and B) . Thus, these results indicate that emodin appears to trigger apoptotic cell death in HepaRG cells.
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